The Anti-Mouse CD44, Biotin (Clone KM81) (rat IgG2a) Antibody from MyBioSource.com is a Rat Monoclonal antibody to CD44, ECMR-III, HCELL, and Pgp1. This antibody recognizes Human, and Mouse antigen. The Anti-Mouse CD44, Biotin (Clone KM81) (rat IgG2a) Antibody has been validated for the following applications: Flow Cytometry, and Immunohistochemistry.
Description
anti-mouse CD44 (Pgp-1, Ly-24) monoclonal antibody recognizes a 95 kDa glycoprotein found on most hematopoietic cells (1). It is thought to be important in the regulation of migratory properties of lymphocytes during development and the regulation of the interaction with bone marrow stromal cells during hematopoiesis (2,3). CD44 functions as a receptor for hyaluronate, although some cells expressing CD44 do not bind hyaluronate (3,4). This antibody has been shown to inhibit the growth of lymphoid and myeloid cells in long term bone marrow cultures (3). It also blocks the adhesive interactions of B cell hybridomas to a cloned stromal line or to hyaluronate coated dishes (4)